Identifying the contributors to students’ academic performance and progress creates an approach for planning, developing, and perfecting educational programs. The present study aimed to investigate the effectiveness of flipped teaching and problem-solving methods on the sense of responsibility and problem-solving ability in mathematics among female high school students in Ahvaz. The research method was quasi-experimental with a pre-test and post-test design and a control group. The statistical population included all female high school students in Ahvaz in 2019. Using the convenience sampling method, 75 students were selected and randomly divided into two experimental groups (flipped teaching and problem-solving method) and a control group (n= 25 per group). The control group received the traditional teaching method. The research instruments included the Responsibility Questionnaire and Problem-Solving Style Questionnaire. Analysis of covariance was used to analyze the data. The results showed that there was a significant difference between the experimental and control groups in productive and unproductive problem-solving styles among the students (p < 0.01). Also, the flipped teaching and problem-solving methods increased the sense of responsibility in the students, compared to the traditional method. According to the results, the effectiveness of flipped teaching was more effective compared to problem-solving methods on the productive and unproductive problem-solving styles and sense of responsibility. Consequently, the flipped teaching and problem-solving methods can be used to promote problem-solving styles and a sense of responsibility among students.